Parkinson's Disease
Mumbai
India
ph: 9821313033
neuro
Parkinson's disease is a chronic disorder that requires broad-based management including patient and family education, support group services, general wellness maintenance, physiotherapy, exercise, and nutrition. One could consult an occupational therapist on a broad range of methods, therapy, and assistive equipment to make Parkinson's more manageable in the areas of personal care, productivity and leisure. At present, there is no cure for PD, but medications or surgery can provide relief from the symptoms.
http://www.gammaknife.in/treatments.html
The most widely used form of treatment is L-dopa in various forms. L-dopa is transformed into dopamine in the dopaminergic neurons by L-aromatic amino acid decarboxylase (often known by its former name dopa-decarboxylase). However, only 1-5% of L-DOPA enters the dopaminergic neurons. The remaining L-DOPA is often metabolised to dopamine elsewhere, causing a wide variety of side effects. .
Carbidopa and benserazide are dopa decarboxylase inhibitors. They help to prevent the metabolism of L-dopa before it reaches the dopaminergic neurons and are generally given as combination preparations of carbidopa/levodopa (co-careldopa) and benserazide/levodopa (co-beneldopa).
The dopamine agonists: bromocriptine, pergolide, pramipexole, ropinirole , piribedil, cabergoline, apomorphine, and lisuride are moderately effective. Dopamine agonists initially act by stimulating some of the dopamine receptors. However, they cause the dopamine receptors to become progressively less sensitive, thereby eventually increasing the symptoms. Dopamine agonists can be useful for patients experiencing on-off fluctuations and dyskinesias as a result of high doses of L-dopa.
Dr.Sanjay Mongia , Neurological Surgeon ,
Ph: 9821313033
Parkinson's Disease
Mumbai
India
ph: 9821313033
neuro